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Les années 2000 sont bien salées:
- 2001: Bernd-Jürgen Brandes, from Germany, was voluntarily stabbed repeatedly and then partly eaten by Armin Meiwes (who was later called the Cannibal of Rotenburg). Brandes had answered an internet advertisement by Meiwes looking for someone for this purpose. Brandes explicitly stated in his will that he wished to be killed and eaten.
- 2001: Michael Colombini, a 6-year-old American boy from Croton-on-Hudson, New York, was struck and killed at Westchester Regional Medical Centre by an oxygen tank when it was pulled into the magnetic resonance imaging (MRI) machine while he underwent a test. He had begun to experience breathing difficulties while in the MRI and when an anaesthesiologist brought a portable oxygen canister into the magnetic field, it was pulled from his hands and struck the boy in the head.
- 2002: Brittanie Cecil, a 13-year-old American, was struck in the head by a hockey puck shot by Espen Knutsen and deflected into the crowd at an NHL hockey game in Columbus, Ohio. She died two days later in the hospital.
- 2002: Richard Sumner, a British artist suffering from schizophrenia, went into a remote section of Clocaenog Forest in Denbighshire, Wales, handcuffed himself to a tree and threw the keys out of his reach. His skeleton was discovered three years later. There were signs that he may have later changed his mind.
- 2003: Brian Douglas Wells, an American pizza delivery man in Erie, Pennsylvania, was killed when a time bomb fastened around his neck exploded. At the time of his death he had been apprehended by the police for robbing a bank. Wells told police that three people had locked the bomb around his neck and would not release it had he refused to commit the robbery.
- 2004: Ronald McClagish, from Murrow, Cambridgeshire in England, was trapped inside a cupboard when a wardrobe outside fell over and made it impossible for him to get out. McClagish survived for a week before succumbing to bronchitis, which he had contracted when he removed a waterpipe in an attempt to free himself and the cupboard was partially flooded.
- 2004: An unidentified Taiwanese woman died of alcohol intoxication after immersion for twelve hours in a bathtub filled with 40% ethanol. Her blood alcohol content was 1.35%. It was believed that she had immersed herself as a response to the SARS epidemic.
- 2004: Francis "Franky" Brohm, 23, of Marietta, Georgia was leaning out of a car window and decapitated by a telephone pole support wire. The car's intoxicated driver, John Hutcherson, 21, drove nearly 12 miles (19 km) to his home with the headless body in the passenger seat, parked the car in his driveway, then went to bed. A neighbour saw the bloody corpse still in the car and notified police. Brohm's head was later discovered at the accident scene.
- 2005: Kenneth Pinyan from Seattle, Washington, died of acute peritonitis after receiving anal intercourse from a stallion. The case led to the criminalization of bestiality in Washington state.
- 2005: Lee Seung Seop, a 28-year-old from South Korea, collapsed of fatigue and died after playing the videogame StarCraft online for almost 50 consecutive hours.
- 2006: Erika Tomanu, a seven-year-old girl in Saitama, Japan, died when she was sucked 10 metres down the intake pipe of a current pool at a water park.
- 2006: An unidentified airline mechanic was sucked into the engine of a Boeing 737-500 at El Paso International Airport while performing routine maintenance on the tarmac.
- 2006: Steve Irwin, an Australian television personality and naturalist known as the Crocodile Hunter, died when his heart was impaled by a short-tail stingray barb while filming a documentary in Queensland's Great Barrier Reef.
- 2006: Mariesa Weber, a petite 38-year-old woman, asphyxiated when she became wedged upside-down behind a bookcase in her bedroom while trying to adjust a plug on her television set. Her family, believing she had been abducted, searched for eleven days before finally finding the body.
- 2006: Alexander Litvinenko, a former officer of the Russian State Security Service and later a dissident and writer, died from acute radiation syndrome after being poisoned withpolonium-210.
- 2007: Jennifer Strange, a 28-year-old woman from Sacramento, California, died of water intoxication while trying to win a Nintendo Wii console in a KDND 107.9 "The End" radio station's "Hold Your Wee for a Wii" contest, which involved drinking large quantities of water without urinating.
- 2007: Humberto Hernandez, a 24-year-old Oakland, California resident, was killed after being struck in the face by an airborne fire hydrant while walking. A passing car had struck the fire hydrant and the water pressure shot the hydrant at Hernandez with enough force to kill him.
- 2007: Kevin Whitrick, a 42-year-old British man, committed suicide by hanging himself live in front of a webcam during an Internet chat session.
- 2007: Surinder Singh Bajwa, the Deputy Mayor of Delhi, India, died after falling from his building's terrace while trying to fight off attacking Rhesus macaque monkeys.
- 2008: Abigail Taylor, a 6-year-old from Edina, Minnesota, died nine months after several of her internal organs were partially sucked out of her lower body while she sat on an excessively powerful swimming pool drain. Surgeons had replaced her intestines and pancreas with donor organs, but she later succumbed to a rare transplant-related cancer.
- 2008: David Phyall, 50, the last resident in a block of flats due to be demolished in Bishopstoke, near Southampton, Hampshire, England, cut off his own head with a chainsaw to highlight the injustice of being forced to move out.
- 2009: Taylor Mitchell, a Canadian folk singer, was attacked and killed by three coyotes, the only recorded adult person to have been killed by this species.